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MPGES1-IN-4

CAT: 0804-HY-139364Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139364Size:1 Each
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Description
MPGES1-IN-4 (compound 32) is a polysubstituted pyrimidine compound and a submicromolar PGE2 production inhibitor. It exerts its anti-inflammatory effect mainly by inhibiting mPGES-1 and has a significant inhibitory effect on the acute inflammation model in vivo.
CAS Number
2253745-78-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/mpges1-in-4.html
Smiles
FC1=C(OCC2=CC=CC=C2)C=CC(C3=C(CCCC)C(C4=CC=CC=C4)=NC(N)=N3)=C1F
Molecular Formula
C27H25F2N3O
Molecular Weight
445.50
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Polysubstituted Pyrimidines as mPGES-1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with Strong Anti-inflammatory Effects in Carrageenan-Induced Rat Paw Edema
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

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