LRRK2-IN-4

LRRK2-IN-4

• CAS Number: 2641054-59-1
• UNSPSC Description: LRRK2-IN-4 is a potent, selective, CNS-penetran and orally active leucine-rich repeat kinase 2 (LRRK2) inhobitor with an IC50 of 2.6 nM. LRRK2-IN-4 has the potential for the research of Parkinson’s disease[1].
• Target Antigen: LRRK2
• Type: Reference compound
• Related Pathways: Autophagy
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/lrrk2-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: FC1([C@](N2C(C)=C(C=N2)NC3=NC4=C(C=C(C(C5CCN([C@@]6([C@@H](COC6)O)C)CC5)=C4)Cl)C=N3)([H])C1)F
• Molecular Weight: 518.99
• References & Citations: [1]Keylor MH, et al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022; 65(1):838-856.|[2]Keylor MH, et al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65(1):838-856.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported