BTK-IN-7

• Description:

  BTK-IN-7 is a potent and selective inhibitor of BTK (IC50=4.0 nM) . BTK-IN-7 has high selectivity in both enzymatic (ITK >250-fold, EGFR >2500-fold) and cellular levels (ITK >227-fold, EGFR 27-fold) . BTK-IN-7 also has potent antitumor activity[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Btk

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/btk-in-7.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(C2=NC(NC3=CC(OCCOC)=CC=C3)=NC=C2N=C1C4CCCCC4)C5=CC=CC(NC(C=C)=O)=C5

• Molecular Formula:

  C30H32N6O4

• Molecular Weight:

  540.61

• References & Citations:

  [1]Dou D, et al. Discovery of Pteridine-7 (8H) -one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK) . J Med Chem. 2022;65 (3) :2694-2709.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2952702-39-3]