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BTK-IN-7

CAT: 0804-HY-143900Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143900Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BTK-IN-7 is a potent and selective inhibitor of BTK (IC50=4.0 nM) . BTK-IN-7 has high selectivity in both enzymatic (ITK >250-fold, EGFR >2500-fold) and cellular levels (ITK >227-fold, EGFR 27-fold) . BTK-IN-7 also has potent antitumor activity[1].
CAS Number
2952702-39-3
UNSPSC
12352005
Target
Apoptosis; Btk
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/btk-in-7.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=NC(NC3=CC(OCCOC)=CC=C3)=NC=C2N=C1C4CCCCC4)C5=CC=CC(NC(C=C)=O)=C5
Molecular Formula
C30H32N6O4
Molecular Weight
540.61
References & Citations
[1]Dou D, et al. Discovery of Pteridine-7 (8H) -one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK) . J Med Chem. 2022;65 (3) :2694-2709.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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