Trk-IN-8

Trk-IN-8

• CAS Number: 2762200-57-5
• UNSPSC Description: Trk-IN-8 is a potent TRK inhibitor with IC50s of 0.42, 0.89 and 1.5 nM for TRKAa, TRKA(G595R) and TRKC(G623R), respectively (WO2021115401A1, compound 3)[1].
• Target Antigen: Trk Receptor
• Type: Reference compound
• Related Pathways: Neuronal Signaling;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/trk-in-8.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N[C@H](C2)C[C@H]2OC3=NC=C(F)C=C3[C@@H](C)/N=C(N4)\C(F)=CN5C4=C1C=N5
• Molecular Weight: 386.36
• References & Citations: [1]Fluorine-containing heterocyclic derivatives with macrocyclic structure and use thereof. WO2021115401A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported