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Trk-IN-8

CAT: 0804-HY-143561Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143561Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trk-IN-8 is a potent TRK inhibitor with IC50s of 0.42, 0.89 and 1.5 nM for TRKAa, TRKA (G595R) and TRKC (G623R), respectively (WO2021115401A1, compound 3) [1].
CAS Number
2762200-57-5
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trk-in-8.html
Solubility
10 mM in DMSO
Smiles
O=C1N[C@H](C2)C[C@H]2OC3=NC=C(F)C=C3[C@@H](C)/N=C(N4)\C(F)=CN5C4=C1C=N5
Molecular Formula
C18H16F2N6O2
Molecular Weight
386.36
References & Citations
[1]Fluorine-containing heterocyclic derivatives with macrocyclic structure and use thereof. WO2021115401A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkC

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