RET-IN-9

CAT: 0804-HY-143546Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-143546Size:1 Each

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Description

RET-IN-9 is a potent inhibitor of RET. RET kinase is a single-pass transmembrane receptor tyrosine kinase that plays an important role in the development of the kidney and enteric nervous system, and the maintenance of homeostasis in the nervous, endocrine, hematopoietic, and male reproductive systems. RET-IN-9 has the potential for the research of RET-related disease including non-small cell lung cancer and medullary thyroid cancer (extracted from patent WO2021115457A1, compound 29) [1].

CAS Number

2649418-11-9

UNSPSC

12352005

Target

RET

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ret-in-9.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(NCC)=CN2N=C1

Molecular Formula

C26H27N9O

Molecular Weight

481.55

References & Citations

[1]Huimin Chen, et al. Pyrazolo[1,5-a]pyridine compounds and preparation method and application thereof. Patent WO2021115457A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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MBS5805858	RET-IN-9
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332425-01	Ret

RET-IN-9

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