ERCC1-XPF-IN-1

ERCC1-XPF-IN-1

• CAS Number: 2411584-25-1
• UNSPSC Description: ERCC1-XPF-IN-1 is a potent and high-affinity ERCC1-XPF inhibitor with IC50 value of 0.49 μM. ERCC1-XPF-IN-1 has the capacity to potentiate the cytotoxicity effect of UV radiation and inhibiting DAN repair, by the inhibition of removal of CPDs, and cyclophosphamide toxicity to colorectal cancer cells[1].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ercc1-xpf-in-1.html
• Purity: 98.62
• Solubility: 10 mM in DMSO
• Smiles: OC1=CC2=C(NC3=CC=C(O)C(CN4CCN(CCN(C)C)CC4)=C3)C5=CC=C(Cl)C=C5N=C2C=C1
• Molecular Weight: 506.04
• References & Citations: [1]Elmenoufy AH, Gentile F, Jay D, et al. Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway. Eur J Med Chem. 2020;204:112658.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported