ERCC1-XPF-IN-1

CAT: 0931-T63464-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T63464-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2411584-25-1

Target

Others, DNA/RNA Synthesis

Related Pathways

DNA Damage/DNA Repair, Others, Cell Cycle/Checkpoint

Bioactivity

ERCC1-XPF-IN-1 is a potent, high-affinity inhibitor of ERCC1-XPF (IC50: 0.49 μM), that inhibits the removal of CPDs, reduces the toxicity of cyclophosphamide to colorectal cancer cells, enhances the cytotoxic effects of UV radiation, and impedes DNA repair.

Smiles

N(C=1C2=C(N=C3C1C=C(O)C=C3)C=C(Cl)C=C2)C4=CC(CN5CCN(CCN(C)C)CC5)=C(O)C=C4

Molecular Formula

C28H32ClN5O2

Molecular Weight

506.04

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Ercc1-xpf-IN-1

CAS Number	2411584-25-1
PubChem CID	162657472
IUPAC Name	6-chloro-9-[3-[[4-[2-(dimethylamino)ethyl]piperazin-1-yl]methyl]-4-hydroxyanilino]acridin-2-ol
Molecular Formula	C28H32ClN5O2
Molecular Weight	506.0
XLogP	4.7
Topological Polar Surface Area	75.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Heavy Atom Count	36
Formal Charge	0
Complexity	693

SMILES

CN(C)CCN1CCN(CC1)CC2=C(C=CC(=C2)NC3=C4C=C(C=CC4=NC5=C3C=CC(=C5)Cl)O)O

InChI

InChI=1S/C28H32ClN5O2/c1-32(2)9-10-33-11-13-34(14-12-33)18-19-15-21(4-8-27(19)36)30-28-23-6-3-20(29)16-26(23)31-25-7-5-22(35)17-24(25)28/h3-8,15-17,35-36H,9-14,18H2,1-2H3,(H,30,31)

InChIKey

BQWNIOWWZCEWFX-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2411584-25-1

CID: 162657472

Formula: C28H32ClN5O2

MW: 506.0

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	506.0
XLogP3	4.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	505.2244530
Monoisotopic Mass	505.2244530
Topological Polar Surface Area	75.1 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	693
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T60904-01	ERCC1-XPF-IN-2
T209886-01	ERCC1/XPA interaction inhibitor 1
TMAC-01359-01	Anti-ERCC1 Antibody (7K54)
TMAC-01358-01	Anti-ERCC1 Antibody (9Q670)
TMAB-05656-01	Anti-ERCC1 Antibody (7W333)
TMAB-05657-01	Anti-ERCC1 Polyclonal Antibody
TMAB-05655-01	Anti-ERCC1 Antibody (5T990)
TMAB-05658-01	Anti-ERCC1 Antibody (5M521)
T5790-01	1,1,1,1-Kestohexaose
T83125-01	AMPK-α1β1γ1 activator 1

Alternative Products

Catalog	Name
HY-143498	ERCC1-XPF-IN-1
BUP09974-01	ERCC1-XPF-IN-2
405600-01	XPF
X1049-01	XPF discontinued
MBS8510787-01	XPF Antibody

ERCC1-XPF-IN-1

Chemical Information

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