ERCC1-XPF-IN-2

ERCC1-XPF-IN-2

• CAS Number: 1808986-37-9
• UNSPSC Description: ERCC1-XPF-IN-2 is a potent ERCC1-XPF endonuclease inhibitor with an IC50 value of 0.6 μM. ERCC1-XPF-IN-2 shows activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays[1].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ercc1-xpf-in-2.html
• Solubility: DMSO : ≥ 250 mg/mL
• Smiles: OC1=C(O)C=C(CNC(CC2=C(Cl)C=C(Cl)C=C2)=O)C=C1
• Molecular Weight: 326.17
• References & Citations: [1]Chapman TM, et al. Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported