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CAXII-IN-1

CAT: 0804-HY-143460Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143460Size:1 Each
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Description
CAXII-IN-1 (Compound 17) is a selective CA XII inhibitor with Ki values of 3.8 nM and 56.0 nM against hCA XII and hCA IX, respectively. CAXII-IN-1 shows antitumor activity[1].
CAS Number
2479918-59-5
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/caxii-in-1.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(Cl)=CC(C2=CN=C(OS(C=C3)(=O)=O)C3=C2)=C1
Molecular Formula
C13H7Cl2NO3S
Molecular Weight
328.17
References & Citations
[1]Grandāne A, et al. Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. Eur J Med Chem. 2020 Aug 15;200:112300.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA XII

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Alternative Products

CatalogName
T60930-01CAXII-IN-1
GTR19264350-01CAII/CAXII-IN-1
T207532-01CAXII-IN-2
GTR19272927-01CAXII-IN-3
T205667-01CAIX/CAXII-IN-4
T210252-01CAIX/CAXII-IN-2
T200520-01CAIX/CAXII-IN-3
P1704-20Active Recombinant Human CAXII Protein
588271CA12 (CAXII, FLJ20151, HsT18816, carbonic dehydratase)
244119CA12 (Carbonic Anhydrase XII, CAXII, FLJ20151, HsT18816)

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