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CAXII-IN-3

CAT: 0804-HY-178030Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178030Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAXII-IN-3 is an effective carbonic anhydrase (CA XII) inhibitor with a Ki of 53 nM. CAXII-IN-3 exhibits selective inhibition against multiple human CA subtypes with Kis of 5.3 μM, 75 nM, 1.9 μM, > 10 μM against CA I, CA II, CA IV and CA IX. CAXII-IN-3 mainly inhibits CA II and XII, and reduces aqueous humor production. CAXII-IN-3 exhibits β3-AR agonistic activity, can dilate retinal blood vessels, and improve optic nerve perfusion. CAXII-IN-3 can be used in the research of ocular disorders such as glaucoma[1].
UNSPSC
12352005
Target
Adrenergic Receptor; Carbonic Anhydrase
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
NC1=CC=C(C=C1)CCNC[C@@H](C2=CC=CC=C2)OC(NC3=CC(C=C4)=C(C=C3)OC4=O)=S
Molecular Formula
C26H25N3O3S
Molecular Weight
459.56
References & Citations
[1]Ammara A, et al. Repurposing Drug Metabolites into Dual β-Adrenergic Receptor-Carbonic Anhydrase Modulators as Potential Tools for Ocular Disorders. J Med Chem. 2025 Sep 11;68 (17) :18579-18596.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I; CA IX; CA XII; β adrenergic receptor

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P1704-50Active Recombinant Human CAXII Protein
588271CA12 (CAXII, FLJ20151, HsT18816, carbonic dehydratase)
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