Cdc7-IN-18

• Description :

  Cdc7-IN-18 (compound 1-2) is a potent CDC7 inhibitor with an IC50 of 1.29 nM for Cdc7/DBF4 enzyme. Cdc7-IN-18 shows antiproliferative activities with IC50 of 53.62 nM in COLO205 cells[1].

• CAS Number :

  [2562329-14-8]

• UNSPSC :

  12352005

• Target :

  CDK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cdc7-in-18.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C2=C(NC([C@]3([H])N4CCC(CC4)C3)=N1)C5=C(C6=CNN=C6CCC5)S2

• Molecular Formula :

  C19H21N5OS

• Molecular Weight :

  367.47

• References & Citations :

  [1]Li Gang, et al. Tetracyclic compounds as cdc7 inhibitors. WO2020239107A1.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDC