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HSP70-IN-3

CAT: 0804-HY-143400Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143400Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSP70-IN-3 is a potent HSP70 inhibitor (IC50s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively) . HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1[1].
UNSPSC
12352005
Target
Hedgehog; HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsp70-in-3.html
Solubility
10 mM in DMSO
Smiles
[H][C@@]12CS[C@@H]([C@@]1(NC(N2)=O)[H])CCCCC(NCCOCCOCCOCCN3C=C(N=N3)CO[C@@H]([C@H]([C@H]4CC[C@]5(/C(CCC[C@]45C)=C/C=C6C[C@H](CCC/6=C)O)[H])C)CCC(C)C)=O
Molecular Formula
C48H78N6O7S
Molecular Weight
883.23
References & Citations
[1]Wen J, et al. Affinity-based protein profiling identifies vitamin D3 as a heat shock protein 70 antagonist that regulates hedgehog transduction in murine basal cell carcinoma. Eur J Med Chem. 2022;228:114005.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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