HSP70-IN-6

HSP70-IN-6

• CAS Number: 3048341-44-9
• UNSPSC Description: HSP70-IN-6 (Compound JL-15) is an inhibitor of Hsp70-Bim protein-protein interaction (PPI) (IC50: 70 nM). HSP70-IN-6 induces apoptosis in chronic myeloid leukemia (CML) cells, with EC50s of 0.43 μM(BV173), 0.88 μM (K562), 0.19 μM (K562-R3)[1].
• Target Antigen: Apoptosis; Bcl-2 Family; HSP
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hsp70-in-6.html
• Smiles: OC1=C(C(NCCN2CCCCC2)=CC(C3=CC=C(C=C3)OC4=CC(C)=C(C(C)=C4)Cl)=C1)C#N
• Molecular Weight: 476.01
• References & Citations: [1]Jiang M, et al. Discovery of Biphenyl Derivatives to Target Hsp70-Bim Protein-Protein Interaction in Chronic Myeloid Leukemia by Scaffold Hopping Strategy. J Med Chem. 2024 Jul 25;67(14):12068-12084.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported