HSP70/SIRT2-IN-1

HSP70/SIRT2-IN-1

• UNSPSC Description: HSP70/SIRT2-IN-1 (Compounds 2a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 17.3±2.0 μM for SIRT2. HSP70/SIRT2-IN-1 has antitumor activity[1].
• Target Antigen: HSP; Sirtuin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/hsp70-sirt2-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC=C(C2=CSC(NC3=CC(SC)=C(CC)C=C3)=N2)C=C1
• Molecular Weight: 360.92
• References & Citations: [1]Elena Abbotto, et al. Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays. Pharmaceuticals (Basel). 2023 Sep 18;16(9):1316.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported