HSP70/SIRT2-IN-1

• UNSPSC Description:

  HSP70/SIRT2-IN-1 (Compounds 2a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 17.3±2.0 μM for SIRT2. HSP70/SIRT2-IN-1 has antitumor activity[1].

• Target Antigen:

  HSP; Sirtuin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/hsp70-sirt2-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CC=C(C2=CSC(NC3=CC(SC)=C(CC)C=C3)=N2)C=C1

• Molecular Weight:

  360.92

• References & Citations:

  [1]Elena Abbotto, et al. Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays. Pharmaceuticals (Basel). 2023 Sep 18;16(9):1316.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported