Tubulin polymerization-IN-2

• UNSPSC Description:

  Tubulin polymerization-IN-2 is a potent anticancer agent targeting to β-tubulin with an IC50 value of 0.92 μM. Tubulin polymerization-IN-2 shows promising activity against various leukemia, non-small lung, renal, prostate, and breast cancer cell lines[1].

• Target Antigen:

  Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tubulin-polymerization-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC2=C(C(C(C#N)=C(O2)N)C3=CC(F)=C(C=C3)F)C=C1

• Molecular Weight:

  314.29

• References & Citations:

  [1]Elshemy HAH, et al. Development of potential anticancer agents and apoptotic inducers based on 4-aryl-4H chromene scaffold: Design, synthesis, biological evaluation and insight on their proliferation inhibition mechanism. Bioorg Chem. 2022 Jan;118:105475.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2873399-22-3