PIM-1/HDAC-IN-1

PIM-1/HDAC-IN-1

• CAS Number: 2897622-19-2
• UNSPSC Description: PIM-1/HDAC-IN-1 (compound 4d) is a PIM-1 inhibitor, with an IC50 of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC50 values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibits apoptosis inducing potential in MCF-7 cell lines. PIM-1/HDAC-IN-1 shows pre-G1 apoptosis and cell cycle arrest at G2/M phase[1].
• Target Antigen: Apoptosis; HDAC; Pim
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics;JAK/STAT Signaling
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pim-1-hdac-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=C(C=C(N=C1OCCCC(NO)=O)C2=CC=CC=C2)C3=CC=CC=C3
• Molecular Weight: 373.40
• References & Citations: [1]Bass AKA, et al. Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors. Bioorg Chem. 2022 Feb;119:105564.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported