PIM-IN-1

PIM-IN-1

• CAS Number: 2698319-19-4
• UNSPSC Description: PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC50 = 61 nM; pS6, EC50 = 71 nM).
• Target Antigen: Pim
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pim-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC(Cl)=C2C(N([C@@H]([C@]3(F)CNCC3)C)C=C2C)=N1)N
• Molecular Weight: 324.78
• References & Citations: [1]Barberis C, et al. Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127625.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported