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NVP-DPP728

CAT: 0804-HY-14292Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14292Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes[1].
CAS Number
247016-69-9
UNSPSC
12352005
Target
Dipeptidyl Peptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nvp-dpp728.html
Solubility
10 mM in DMSO
Smiles
N#CC(C=N1)=CC=C1NCCNCC(N2[C@@H](CCC2)C#N)=O
Molecular Formula
C15H18N6O
Molecular Weight
298.34
References & Citations
[1]Hughes TE, et al. NVP-DPP728 (1-[[[2-[ (5-cyanopyridin-2-yl) amino]ethyl]amino]acetyl]-2-cyano- (S) - pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry. 1999;38 (36) :11597-11603.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
DPP-4

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