NVP-DPP728

• Description :

  NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes[1].

• CAS Number :

  [247016-69-9]

• UNSPSC :

  12352005

• Target :

  Dipeptidyl Peptidase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/nvp-dpp728.html

• Solubility :

  10 mM in DMSO

• Smiles :

  N#CC(C=N1)=CC=C1NCCNCC(N2[C@@H](CCC2)C#N)=O

• Molecular Formula :

  C15H18N6O

• Molecular Weight :

  298.34

• References & Citations :

  [1]Hughes TE, et al. NVP-DPP728 (1-[[[2-[ (5-cyanopyridin-2-yl) amino]ethyl]amino]acetyl]-2-cyano- (S) - pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry. 1999;38 (36) :11597-11603.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  DPP-4