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LIMK-IN-1

CAT: 0804-HY-14227Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14227Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LIMK-IN-1 (Compound 14) is a LIMK1/2 inhibitor (IC50: 0.5 nM and 0.9 nM respectively) . LIMK-IN-1 can be used for research of ocular hypertension and associated glaucoma[1].
CAS Number
1116571-01-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
LIM Kinase (LIMK) ; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/limk-in-1.html
Purity
99.33
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1=CNC2=NC=NC(N3C[C@H](C)N(/C(NC4=CC=CC(Br)=C4)=N\C#N)CC3)=C21
Molecular Formula
C20H21BrN8
Molecular Weight
453.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Harrison BA, et.al. Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52 (21) :6515-8. |[2]Harrison BA, et al. Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52 (21) :6515-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LIMK1; LIMK2; ROCK1; ROCK2

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