Aurora/LIM kinase-IN-1

• UNSPSC Description:

  Aurora/LIM kinase-IN-1 (Compound F114) is a potent and dual inhibitor of aurora and lim kinase. Aurora kinases and lim kinases are involved in neoplastic cell division and cell motility, respectively. Aurora/LIM kinase-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM kinase-IN-1 is a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future agent development efforts for GBM, and potentially other cancers[1].

• Target Antigen:

  Aurora Kinase; LIM Kinase (LIMK)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/aurora-lim-kinase-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(N1C=C(C=N1)NC2=NC=C3C=CC(N(C3=N2)C(C)C)=O)C

• Molecular Weight:

  312.37

• References & Citations:

  [1]Rybin MJ, et al. A dual aurora and lim kinase inhibitor reduces glioblastoma proliferation and invasion. Bioorg Med Chem Lett. 2022;61:128614.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported