Aurora/LIM kinase-IN-1

Aurora/LIM kinase-IN-1

• UNSPSC Description: Aurora/LIM kinase-IN-1 (Compound F114) is a potent and dual inhibitor of aurora and lim kinase. Aurora kinases and lim kinases are involved in neoplastic cell division and cell motility, respectively. Aurora/LIM kinase-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM kinase-IN-1 is a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future agent development efforts for GBM, and potentially other cancers[1].
• Target Antigen: Aurora Kinase; LIM Kinase (LIMK)
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/aurora-lim-kinase-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC(N1C=C(C=N1)NC2=NC=C3C=CC(N(C3=N2)C(C)C)=O)C
• Molecular Weight: 312.37
• References & Citations: [1]Rybin MJ, et al. A dual aurora and lim kinase inhibitor reduces glioblastoma proliferation and invasion. Bioorg Med Chem Lett. 2022;61:128614.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported