RMC-3943

• Description:

  RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM) [1].

• UNSPSC:

  12352005

• Target:

  Phosphatase; SHP2

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/rmc-3943.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N[C@H]1C2(CCC1)CCN(C3=NC(N)=C(N=C3)SC4=CC=NC(Cl)=C4Cl)CC2

• Molecular Formula:

  C18H22Cl2N6S

• Molecular Weight:

  425.38

• References & Citations:

  [1]Efficacy of SHP2 phosphatase inhibition in cancers with nucleotide-cycling oncogenic RAS, RAS-GTP dependent oncogenic BRAF and NF1 loss. BioRxiv. 2021 Aug.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1801764-60-2]