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RMC-3943

CAT: 0804-HY-141524Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-141524Size:1 Each
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Description
RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM) [1].
CAS Number
1801764-60-2
UNSPSC
12352005
Target
Phosphatase; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rmc-3943.html
Solubility
10 mM in DMSO
Smiles
N[C@H]1C2(CCC1)CCN(C3=NC(N)=C(N=C3)SC4=CC=NC(Cl)=C4Cl)CC2
Molecular Formula
C18H22Cl2N6S
Molecular Weight
425.38
References & Citations
[1]Efficacy of SHP2 phosphatase inhibition in cancers with nucleotide-cycling oncogenic RAS, RAS-GTP dependent oncogenic BRAF and NF1 loss. BioRxiv. 2021 Aug.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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