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RMC-6291

CAT: 0931-T75131-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T75131-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2641998-63-0
Target
Apoptosis, ERK, Ras, Kras
Related Pathways
MAPK, Apoptosis, GPCR/G Protein
Purity
0.9992
Bioactivity
RMC-6291 is an orally active, covalent inhibitor of KRAS G12C (ON) that forms a tri-complex within tumor cells between KRAS G12C (ON) and cyclophilin A (CypA), thereby preventing KRAS G12C (ON) from signaling via steric blockade of RAS effector binding and eliciting deep and durable suppression of RAS pathway activity in KRAS G12C tumor models [1].
Smiles
CCN1C2=C3C=C(C=C2)N4CCO[C@H](C4)C[C@@H](C(=O)N5CCC[C@H](N5)C(=O)OCC(CC3=C1C6=C(N=CC=C6)[C@H](C)OC)(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)C7(CCN(CC7)C(=O)C#CC(C)(C)N(C)C)F
Molecular Formula
C55H78FN9O8
Molecular Weight
1012.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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