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Thalidomide-O-PEG4-amine (TFA)

CAT: 0804-HY-141010BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-141010BSize:1 Each
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Description
Thalidomide-O-PEG4-amine TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
CAS Number
2934561-88-1
UNSPSC
12352005
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-o-peg4-amine-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCN)=O.O=C(O)C(F)(F)F
Molecular Formula
C25H32F3N3O11
Molecular Weight
607.53
References & Citations
[1]Zhang NN, et al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020;182 (5) :1271-1283.e16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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