Thalidomide-O-PEG4-NHS ester

• UNSPSC Description:

  Thalidomide-O-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

• Target Antigen:

  Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-o-peg4-nhs-ester.html

• Solubility:

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles:

  O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O

• Molecular Weight:

  619.57

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  2411681-88-2