Azido-PEG1-C2-methylamine

CAT: 0804-HY-140221-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-140221-01Size:25 mg

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Description

Azido-PEG1-C2-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-C2-methylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

CAS Number

1835759-88-0

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azido-peg1-c2-methylamine.html

Solubility

10 mM in DMSO

Smiles

[N-]=[N+]=NCCOCCNC

Molecular Formula

C5H12N4O

Molecular Weight

144.17

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Chemical Information

Azido-PEG1-methylamine

CAS Number	1835759-88-0
PubChem CID	57765145
IUPAC Name	2-(2-azidoethoxy)-N-methylethanamine
Molecular Formula	C5H12N4O
Molecular Weight	144.18
XLogP	0.6
Topological Polar Surface Area	35.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Heavy Atom Count	10
Formal Charge	0
Complexity	110

SMILES

CNCCOCCN=[N+]=[N-]

InChI

InChI=1S/C5H12N4O/c1-7-2-4-10-5-3-8-9-6/h7H,2-5H2,1H3

InChIKey

DRMPMTBZYHVFIA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1835759-88-0

CID: 57765145

Formula: C5H12N4O

MW: 144.18

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	144.18
XLogP3	0.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	144.10111102
Monoisotopic Mass	144.10111102
Topological Polar Surface Area	35.6 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	110
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-140009-01	Azido-PEG1-C2-acid
HY-138474	Boc-PEG1-PPG2-C2-azido
HY-133390-01	Azido-PEG1-azide
HY-138461-01	Azido-PEG1
HY-140819-01	Bromo-PEG1-C2-azide
HY-140101	Azido-C2-SS-PEG2-C2-acid
HY-108369-01	Azido-PEG1-CH2CO2H
HY-140212-01	Azido-PEG1-amine
HY-140775-01	Azido-PEG1-Boc
HY-140213-01	Azido-PEG2-C2-amine

Alternative Products

Catalog	Name
GTR19226705-01	Azido-PEG1-C2-methylamine
571851	Azido-PEG1-methylamine
T14405-01	Azido-PEG1-C2-acid
T207998-01	Boc-PEG1-PPG2-C2-azido
OR1036499-01	Azido-PEG1
T32120-01	Hydroxy-PEG1-methylamine
MBS3613759-01	Azido-PEG1-azide
sc-496108	Azido-PEG1-Amine
MBS5768498	Azido-PEG1-CH2CO2H
T14403-01	Azido-PEG1-Boc

Azido-PEG1-C2-methylamine

Chemical Information

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