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Dasabuvir (sodium)

CAT: 0804-HY-13998ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13998ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dasabuvir (ABT-333) sodium is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir sodium inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively[1].
CAS Number
1132940-11-4
Product Name Alternative
ABT-333 (sodium)
UNSPSC
12352005
Target
DNA/RNA Synthesis; HCV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dasabuvir-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C1C=CN(C2=CC(C(C)(C)C)=C(OC)C(C3=CC=C4C=C(NS(=O)(C)=O)C=CC4=C3)=C2)C(N1)=O.[Na]
Molecular Formula
C26H27N3NaO5S
Molecular Weight
516.56
References & Citations
[1]Kati W, et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2015 Mar;59 (3) :1505-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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