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Briciclib (sodium)

CAT: 0804-HY-16366ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-16366ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Briciclib (ON 014185) sodium is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib sodium exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib sodium reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib sodium can be used for the study of hematological system tumors and solid tumors[1].
CAS Number
[865784-01-6]
Product Name Alternative
ON 014185 (sodium)
UNSPSC
12352005
Target
Apoptosis; Caspase; CDK; c-Myc; Eukaryotic Initiation Factor (eIF) ; MDM-2/p53
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=S(CC1=CC(OP(O[Na])(O[Na])=O)=C(OC)C=C1)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O
Molecular Formula
C19H21Na2O10PS
Molecular Weight
518.38
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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S6533-2mgBriciclib
T68506-01Briciclib Na
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A21313-50Briciclib 50mg
A21313-100Briciclib 100mg
A21313-500Briciclib 500mg
A21313-2Briciclib 2mg
A21313-5Briciclib 5mg
A21313-1Briciclib 1mg
A21313-10Briciclib 10mg

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