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(S) -CCG-1423

CAT: 0804-HY-13991ASize: 1 EachDry Ice: NoHazardous: No
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Description
(S) -CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S) -CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S) -CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423. (S) -CCG-1423 can be used for the research of cancer and diabetes[1].
CAS Number
2319939-24-5
UNSPSC
12352005
Hazard Statement
H225-H350
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s-ccg-1423.html
Solubility
10 mM in DMSO
Smiles
O=C(NO[C@@H](C)C(NC1=CC=C(Cl)C=C1)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
Molecular Formula
C18H13ClF6N2O3
Molecular Weight
454.75
Precautions
P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P405-P501
References & Citations
[1]Watanabe B, et al. Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A. PLoS One. 2015 Aug 21;10 (8) :e0136242.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(S)-N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide
CAS Number2319939-24-5
PubChem CID40782279
IUPAC NameN-[(2S)-1-(4-chloroanilino)-1-oxopropan-2-yl]oxy-3,5-bis(trifluoromethyl)benzamide
Molecular FormulaC18H13ClF6N2O3
Molecular Weight454.7
XLogP4.9
Topological Polar Surface Area67.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity586
SMILES
C[C@@H](C(=O)NC1=CC=C(C=C1)Cl)ONC(=O)C2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F
InChI
InChI=1S/C18H13ClF6N2O3/c1-9(15(28)26-14-4-2-13(19)3-5-14)30-27-16(29)10-6-11(17(20,21)22)8-12(7-10)18(23,24)25/h2-9H,1H3,(H,26,28)(H,27,29)/t9-/m0/s1
InChIKey
DSMXVSGJIDFLKP-VIFPVBQESA-N
Chemical Structure
2D Structure
2D structure of (S)-N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide
CAS: 2319939-24-5
CID: 40782279
Formula: C18H13ClF6N2O3
MW: 454.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight454.7
XLogP34.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass454.0518889
Monoisotopic Mass454.0518889
Topological Polar Surface Area67.4 Ų
Heavy Atom Count30
Formal Charge0
Complexity586
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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