Trk-IN-6

• Description:

  Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants (IC50 = 0.2-0.7 nM) .

• UNSPSC:

  12352005

• Target:

  Trk Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/trk-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC=C (OCC (F) F) C ([C@@H] (C) NC2=NC3=C (C4=CN (CCO) N=C4) C=NN3C=C2) =C1

• Molecular Formula:

  C21H21F3N6O2

• Molecular Weight:

  446.43

• References & Citations:

  [1]Zhuo LS, et al. Discovery of Next-Generation Tropomyosin Receptor Kinase Inhibitors for Combating Multiple Resistance Associated with Protein Mutation. J Med Chem. 2021 Oct 28;64 (20) :15503-15514.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2489327-43-5