Trk-IN-6

• Description :

  Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants (IC50 = 0.2-0.7 nM) .

• UNSPSC :

  12352005

• Target :

  Trk Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/trk-in-6.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC=C(OCC(F)F)C([C@@H](C)NC2=NC3=C(C4=CN(CCO)N=C4)C=NN3C=C2)=C1

• Molecular Formula :

  C21H21F3N6O2

• Molecular Weight :

  446.43

• References & Citations :

  [1]Zhuo LS, et al. Discovery of Next-Generation Tropomyosin Receptor Kinase Inhibitors for Combating Multiple Resistance Associated with Protein Mutation. J Med Chem. 2021 Oct 28;64 (20) :15503-15514.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2489327-43-5]