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Trk-IN-6

CAT: 0804-HY-139891Size: 1 EachDry Ice: NoHazardous: No
HY-1398911 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants (IC50 = 0.2-0.7 nM) .
CAS Number
[2489327-43-5]
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trk-in-6.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(OCC(F)F)C([C@@H](C)NC2=NC3=C(C4=CN(CCO)N=C4)C=NN3C=C2)=C1
Molecular Formula
C21H21F3N6O2
Molecular Weight
446.43
References & Citations
[1]Zhuo LS, et al. Discovery of Next-Generation Tropomyosin Receptor Kinase Inhibitors for Combating Multiple Resistance Associated with Protein Mutation. J Med Chem. 2021 Oct 28;64 (20) :15503-15514.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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