MCX 28

• Description:

  MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.

• UNSPSC:

  12352005

• Target:

  MTOR; PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mcx-28.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(C2=CN=C(OC)C(NS3(=O)=O)=C2)SC4=C1N=CN=C4C5=CC=C(CNC(C6=CC3=CC=C6)=O)S5

• Molecular Formula:

  C25H19N5O4S3

• Molecular Weight:

  549.64

• References & Citations:

  [1]Martínez-González S, et al. Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors. ACS Med Chem Lett. 2021 Nov 2;12 (11) :1794-1801.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1414453-58-9