Thalidomide-5-PEG3-NH2

CAT: 0804-HY-138786Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-138786Size:1 Each
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Description
Thalidomide-5-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
CAS Number
[2743432-13-3]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-5-peg3-nh2.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C2CCC(NC2=O)=O)C3=CC=C(OCCOCCOCCN)C=C3C1=O
Molecular Formula
C19H23N3O7
Molecular Weight
405.40
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-995.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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