Thalidomide-5-NH-PEG3-NH2 (hydrochloride)

Thalidomide-5-NH-PEG3-NH2 (hydrochloride)

• CAS Number: 2863635-01-0
• UNSPSC Description: Thalidomide-5-NH-PEG3-NH2 hydrochloride is a Thalidomide (HY-14658)-based cereblon ligand that recruits CRBN proteins. Thalidomide-5-NH-PEG3-NH2 hydrochloride can be connected to the target protein ligand through a linker to form a PROTAC molecule. For example, THAL-SNS-032 (HY-123937).
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/thalidomide-5-nh-peg3-nh2-hydrochloride.html
• Purity: 98.04
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC(C(CC1)N2C(C3=CC=C(NCCOCCOCCOCCN)C=C3C2=O)=O)=O.Cl
• Molecular Weight: 484.93
• References & Citations: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.  [Content Brief]
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported