Thalidomide-5-PEG2-NH2 (hydrochloride)

Thalidomide-5-PEG2-NH2 (hydrochloride)

• CAS Number: 2761406-70-4
• UNSPSC Description: Thalidomide-5-PEG2-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-PEG2-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/thalidomide-5-peg2-nh2-hydrochloride.html
• Purity: 99.65
• Solubility: 10 mM in DMSO
• Smiles: O=C1C(N2C(C3=C(C2=O)C=CC(OCCOCCN)=C3)=O)CCC(N1)=O.Cl
• Molecular Weight: 397.81
• References & Citations: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.  [Content Brief]
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported