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DGTP-d14 (dilithium)

CAT: 0804-HY-138616S1Size: 1 mg (100 mM in 18.76 μL Tris HCl/D2O buffer pH=7.5)Dry Ice: NoHazardous: No
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CAT#:0804-HY-138616S1Size:1 mg (100 mM in 18.76 μL Tris HCl/D2O buffer pH=7.5)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DGTP-d14 (2'-Deoxyguanosine-5'-triphosphate-d14) dilithium is deuterium labeled dGTP. dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
Product Name Alternative
2'-Deoxyguanosine-5'-triphosphate-d14 (dilithium)
UNSPSC
12352005
Target
DNA/RNA Synthesis; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Others
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Concentration
100 mM in 18.76 μL Tris HCl/D2O buffer pH=7.5
Purity
98.5
Solubility
10 mM in DMSO
Smiles
O=P(O[2H])(O[Li])OP(OP(OC([2H])([2H])[C@@]1([2H])O[C@](N2C(N=C(N([2H])[2H])N([2H])C3=O)=C3N=C2[2H])([2H])C([2H])([2H])[C@]1([2H])O[2H])(O[2H])=O)(O[Li])=O
Molecular Formula
C10D14Li2N5O13P3
Molecular Weight
533.13
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202 (1) :e00567-19. Published 2019 Dec 6.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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