DGTP-d14 (dilithium)

• Description :

  DGTP-d14 (2'-Deoxyguanosine-5'-triphosphate-d14) dilithium is deuterium labeled dGTP (HY-138616) . dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

• Product Name Alternative :

  2'-Deoxyguanosine-5'-triphosphate-d14 (dilithium)

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Cell Cycle/DNA Damage; Others

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection

• Concentration :

  100 mM in 18.76 μL Tris HCl/D2O buffer pH=7.5

• Purity :

  98.5

• Solubility :

  10 mM in DMSO

• Smiles :

  O=P(O[2H])(O[Li])OP(OP(OC([2H])([2H])[C@@]1([2H])O[C@](N2C(N=C(N([2H])[2H])N([2H])C3=O)=C3N=C2[2H])([2H])C([2H])([2H])[C@]1([2H])O[2H])(O[2H])=O)(O[Li])=O

• Molecular Formula :

  C10D14Li2N5O13P3

• Molecular Weight :

  533.13

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202 (1) :e00567-19. Published 2019 Dec 6.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Solution, -20°C, 2 years

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported