dGTP-15N5 (dilithium)

dGTP-15N5 (dilithium)

• CAS Number: 95648-75-2
• UNSPSC Description: dGTP-15N5 (2'-Deoxyguanosine-5'-triphosphate-15N5) dilithium is 15N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
• Target Antigen: DNA/RNA Synthesis; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage;Others
• Applications: COVID-19-anti-virus
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/dgtp-15n5-dilithium.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H]1C[C@H]([15N]2C([15N]=C([15NH2])[15NH]C3=O)=C3[15N]=C2)O[C@@H]1COP(OP(OP(O[Li])(O[Li])=O)(O)=O)(O)=O
• Molecular Weight: 524.01
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported