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ATP-d14 (dilithium)

CAT: 0804-HY-B2176S4Size: 1 mg (100 mM in 18.76 μL Tris HCl/D2O buffer pH=7.5)Dry Ice: NoHazardous: No
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CAT#:0804-HY-B2176S4Size:1 mg (100 mM in 18.76 μL Tris HCl/D2O buffer pH=7.5)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ATP-d14 (Adenosine 5'-triphosphate-d14) dilithium is deuterium labeled ATP. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
Product Name Alternative
Adenosine 5'-triphosphate-d14 (dilithium)
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Concentration
100 mM in 18.76 μL Tris HCl/D2O buffer pH=7.5
Purity
99.30
Solubility
10 mM in DMSO
Smiles
O=P(O[2H])(O[Li])OP(OP(OC([2H])([2H])[C@@]1([2H])O[C@](N2C3=NC([2H])=NC(N([2H])[2H])=C3N=C2[2H])([2H])[C@](O[2H])([2H])[C@]1([2H])O[2H])(O[2H])=O)(O[Li])=O
Molecular Formula
C10D14Li2N5O13P3
Molecular Weight
533.13
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35 (3) :852-8.|[3]M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112 (2) :358-404.|[4]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.|[5]Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8 (5) : e63759.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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