dGTP-13C10,15N5 (dilithium)

• UNSPSC Description:

  dGTP-13C10,15N5 (2'-Deoxyguanosine-5'-triphosphate-13C10,15N5) dilithium is 13C and 15N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

• Target Antigen:

  DNA/RNA Synthesis; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Cell Cycle/DNA Damage;Others

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/dgtp-13c10-15n5-dilithium.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P(O)(O[Li])OP(OP(O[13CH2][13C@H]1O[13C@@H]([15N]2[13C]([15N]=[13C]([15NH2])[15NH][13C]3=O)=[13C]3[15N]=[13CH]2)[13CH2][13C@@H]1O)(O)=O)(O[Li])=O

• Molecular Weight:

  533.94

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported