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Multitarget AD inhibitor-1

CAT: 0804-HY-136813Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-136813Size:1 Each
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Description
Multitarget AD inhibitor-1 is a selective and reversible butyrylcholinesterase (BuChE) inhibitor with IC50s of 7.22 μM and 1.55 μM for hBuChE and eqBuChE (BuChE from equine serum), respectively. Multitarget AD inhibitor-1 inhibits β-secretase (IC50hBACE-1=41.60 μM), amyloid β aggregation (IC50Aβ=3.09 μM), tau aggregation. Multitarget AD inhibitor-1, a diphenylpropylamine derivative, has the potential for multifunctional disease-modifying anti-Alzheimer’s research[1].
CAS Number
2205015-77-4
UNSPSC
12352005
Target
Amyloid-β; Beta-secretase; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/multitarget-ad-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
OC(CNCC1=CC=CC(C(C)(C)C)=C1)CNCCC(C2=CC=CC=C2)C3=CC=CC=C3
Molecular Formula
C29H38N2O
Molecular Weight
430.62
References & Citations
[1]Dawid Panek, et al. Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents. ACS Chem Neurosci. 2018 May 16;9 (5) :1074-1094.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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