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Multitarget AD inhibitor-2

CAT: 0804-HY-158978Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158978Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Multitarget AD inhibitor-2 (Compound VN-19) is a multitargeting inhibitor acetylcholinesterase (AChE, IC50=0.14 μM), butyrylcholinesterase (BChE, IC50=11.6 μM), monoamine oxidase B (MAO B, IC50=0.45 μM). Multitarget AD inhibitor-2 inhibits self-induced aggregation of amyloid beta protein Aβ1-42 (inhibition rate is 47.3% at 20 μM), and downregulates the level of ROS in SH-SY5Y (80 inhibition rate at 25 μM). Multitarget AD inhibitor-2 ameliorates the cognitive decline in Scopolamine -induced Alzheimer’s Disease zebrafish models[1].
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/multitarget-ad-inhibitor-2.html
Smiles
O=C1C=C(C2=CC=C(OCCN3CCCC3)C(OC)=C2)OC4=C1C=CC=C4
Molecular Formula
C22H23NO4
Molecular Weight
365.42
References & Citations
[1]Kumar N, et al. In Vitro and In Vivo Investigations of Chromone Derivatives as Potential Multitarget-Directed Ligands: Cognitive Amelioration Utilizing a Scopolamine-Induced Zebrafish Model. ACS Chem Neurosci. 2024 May 25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; MAO-B

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