2'-Deoxyadenosine-5'-triphosphate-13C10 (dilithium)

• UNSPSC Description:

  2'-Deoxyadenosine-5'-triphosphate-13C10 (dATP-13C10) dilithium is 13C-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

• Target Antigen:

  DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/2-deoxyadenosine-5-triphosphate-13c10-dilithium.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P(O)(O[Li])OP(OP(O[13CH2][13C@H]1O[13C@@H](N2[13C]3=N[13CH]=N[13C](N)=[13C]3N=[13CH]2)[13CH2][13C@@H]1O)(O)=O)(O[Li])=O

• Molecular Weight:

  512.97

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]P J Romaniuk, A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. J Biol Chem. 1982 Jul 10;257(13):7684-8.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported