Adenosine 5'-triphosphate-13C10,15N5 (dilithium)

Adenosine 5'-triphosphate-13C10,15N5 (dilithium)

• UNSPSC Description: Adenosine 5'-triphosphate-13C10,15N5 dilithium is 13C and 15N labeled dilithium salt form of Adenosine 5'-triphosphate (HY-B2176). Adenosine 5'-triphosphate is a central component of energy storage and metabolism in vivo. Adenosine 5'-triphosphate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. Adenosine 5'-triphosphate is an important endogenous signaling molecule in immunity and inflammation[1][2][3][4][5].
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Others
• Field of Research: Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/adenosine-5-triphosphate-13c10-15n5-dilithium.html
• Smiles: OP(OP(OP(O[13CH2][13C@H]1O[13C@H]([13C@@H]([13C@@H]1O)O)[15N]2[13C]3=[13C]([15N]=[13CH]2)[13C]([15NH2])=[15N][13CH]=[15N]3)(O[Li])=O)(O[Li])=O)(O)=O
• Molecular Weight: 533.94
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.|[3]M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.|[4]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.|[5]Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported