2'-Deoxyadenosine-5'-triphosphate-15N5 (dilithium)

2'-Deoxyadenosine-5'-triphosphate-15N5 (dilithium)

• UNSPSC Description: 2'-Deoxyadenosine-5'-triphosphate-15N5 (dATP-15N5) dilithium is 15N labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
• Target Antigen: DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/2-deoxyadenosine-5-triphosphate-15n5-dilithium.html
• Solubility: 10 mM in DMSO
• Smiles: O=P(O)(O[Li])OP(OP(OC[C@H]1O[C@@H]([15N]2C3=[15N]C=[15N]C([15NH2])=C3[15N]=C2)C[C@@H]1O)(O)=O)(O[Li])=O
• Molecular Weight: 508.01
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]P J Romaniuk, A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. J Biol Chem. 1982 Jul 10;257(13):7684-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported