MRS2395

CAT: 0804-HY-136501Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-136501Size:5 mg
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Description
MRS2395, an dipivaloyl derivative, is a potent P2Y12 receptor antagonist. MRS2395 inhibits ADP-induced platelet activation with a Ki of 3.6 μM. MRS2395 inhibits cAMP induced by ADP in rat platelets in the presence of PGE1 with an IC50 of 7 µM. MRS2395 enhances platelet dense granule release in response to TRAP-6[1][2].
CAS Number
[491611-55-3]
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mrs2395.html
Solubility
10 mM in DMSO
Smiles
CNC1=C2N=CN(CC(COC(C(C)(C)C)=O)COC(C(C)(C)C)=O)C2=NC(Cl)=N1
Molecular Formula
C20H30ClN5O4
Molecular Weight
439.94
References & Citations
[1]Bin Xu, et al.Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: phosphate substitution leads to multiple pathways of inhibition of platelet aggregation. J Med Chem. 2002 Dec 19;45 (26) :5694-709. |[2]Annachiara Mitrugno, et al. Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y 12 signaling with MRS2395. Platelets. 2018 Jun;29 (4) :383-394.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y12 Receptor

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