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Estramustine phosphate

CAT: 0804-HY-13627ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13627ASize:1 Each
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Description
Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer[1][2][3].
CAS Number
4891-15-0
UNSPSC
12352005
Hazard Statement
H301-H311-H331-H341
Target
Apoptosis; Microtubule/Tubulin; Mitosis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/estramustine-phosphate.html
Solubility
10 mM in DMSO
Smiles
O=C(OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](OP(O)(O)=O)CC[C@@]4([H])[C@]3([H])CCC2=C1)N(CCCl)CCCl
Molecular Formula
C23H32Cl2NO6P
Molecular Weight
520.38
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501
References & Citations
[1]C Wei, et al. Estramustine phosphate induces prostate cancer cell line PC3 apoptosis by down-regulating miR-31 levels. Eur Rev Med Pharmacol Sci. 2018 Jan;22 (1) :40-45. |[2]Sonja S Mojsilovic, et al. Estramustine Phosphate Inhibits TGF- β-Induced Mouse Macrophage Migration and Urokinase-Type Plasminogen Activator Production. Anal Cell Pathol (Amst) . 2018 Sep 2;2018:3134102. |[3]Stephane Oudard, et al. Activity of docetaxel with or without estramustine phosphate versus mitoxantrone in androgen dependent and independent human prostate cancer xenografts. J Urol. 2003 May;169 (5) :1729-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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