Estramustine

• Description :

  Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H351, H360

• Target :

  Microtubule/Tubulin; Mitosis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/estramustine.html

• Concentration :

  10mM

• Purity :

  99.15

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(OC(N(CCCl)CCCl)=O)C=C4CC3

• Molecular Formula :

  C23H31Cl2NO3

• Molecular Weight :

  440.40

• Precautions :

  H351, H360

• References & Citations :

  [1]Dahllöf B, et al. Estramustine depolymerizes microtubules by binding to tubulin. Cancer Res. 1993 Oct 1;53 (19) :4573-81.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [2998-57-4]