Estramustine (Standard)

• Description :

  Estramustine (Standard) is the analytical standard of Estramustine. This product is intended for research and analytical applications. Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts[1].

• UNSPSC :

  12352005

• Target :

  Microtubule/Tubulin; Mitosis; Reference Standards

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton; Others

• Field of Research :

  Cancer

• Smiles :

  C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(OC(N(CCCl)CCCl)=O)C=C4CC3

• Molecular Formula :

  C23H31Cl2NO3

• Molecular Weight :

  440.40

• References & Citations :

  [1]Dahllöf B, et al. Estramustine depolymerizes microtubules by binding to tubulin. Cancer Res. 1993 Oct 1;53 (19) :4573-81.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [2998-57-4]