Deflazacort-d5

Deflazacort-d5

• UNSPSC Description: Deflazacort-d5 is the deuterium labeled Deflazacort. Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant[1].
• Target Antigen: Glucocorticoid Receptor; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Immunology/Inflammation;Others;Vitamin D Related/Nuclear Receptor
• Field of Research: Inflammation/Immunology; Endocrinology
• Solubility: 10 mM in DMSO
• Smiles: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@@]4(C(C([2H])([2H])OC(C)=O)=O)N=C(C([2H])([2H])[2H])O5)=C1
• Molecular Weight: 446.55
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Mollmann, H., et al., Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone. Pharmaceutical research, 1995. 12(7): p. 1096-1100.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported