Deflazacort

• Description:

  Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  Glucocorticoid Receptor

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/Deflazacort.html

• Concentration:

  10mM

• Purity:

  99.84

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C1C=C[C@@]2 (C) C (CC[C@]3 ([H]) [C@]2 ([H]) [C@@H] (O) C[C@@]4 (C) [C@@]3 ([H]) C[C@]5 ([H]) [C@@]4 (C (COC (C) =O) =O) N=C (C) O5) =C1

• Molecular Formula:

  C25H31NO6

• Molecular Weight:

  441.52

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Mollmann, H., et al., Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone. Pharmaceutical research, 1995. 12 (7) : p. 1096-1100.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  14484-47-0