DBCO-PEG4-DBCO

• Description :

  DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC :

  12352203

• Hazard Statement :

  H315, H319

• Target :

  ADC Linker; PROTAC Linkers

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dbco-peg4-dbco.html

• Purity :

  97.39

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NCCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O)CCOCCOCCOCCOCCC(NCCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O

• Molecular Formula :

  C48H50N4O8

• Molecular Weight :

  810.93

• Precautions :

  H315, H319

• References & Citations :

  [1]Adam TIBBLES, et al. Engineered O-glycosylation in recombinant polypeptides via heterologous glycosylation sites. WO2019122234A1.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker; PEG Linkers

• CAS Number :

  [2182601-68-7]