Alaproclate (hydrochloride)

• UNSPSC Description:

  Alaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow[1][2].

• Target Antigen:

  5-HT Receptor; iGluR; Serotonin Transporter

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/alaproclate-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC(C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O.[H]Cl

• Molecular Weight:

  292.20

• References & Citations:

  [1]Campagna J, et al. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 Dec 4;8(1):17574.|[2]Wilkinson A, et al. Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow.

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  Store at room temperature, keep dry and cool

• Clinical Information:

  No Development Reported

• CAS Number:

  60719-83-7